The Maurice fully automated protein characterization system is the gold standard for detecting molecular weight and charge variants of biomolecule protein drugs. Adopting assembly free card box design and innovative real-timeFull column imaging with isoelectric focusing technology, while also possessingThe capillary electrophoresis of CE-SDS and iCIEF detection modes conforms to the 2020 edition of the Chinese Pharmacopoeia.

CE-SDS：

The purity of antibody drugs directly reflects the level of purification process and the quality of the product. determineCommon methods for antibody purity includeSDS-PAGE method and capillary electrophoresis (CE-SDS), etc. Due to the fact that CE-SDS detection does not require secondary processing of the results, its results are more accurate, stable, and objective than SDS-PAGE. The 2020 Chinese Pharmacopoeia has clear requirements for the purity of monoclonal antibodies detected by CE-SDS: the purity of recombinant monoclonal antibody products is quantitatively determined using sodium dodecyl sulfate capillary electrophoresis (CE-SDS) ultraviolet detection method under reducing and non reducing conditions based on molecular weight size.

iCIEF：

Charge change is one of the most sensitive and rapid methods for determining the degradation variation of antibody drugsWidely adopted by domestic and foreign biopharmaceutical companies. Unlike traditional single point detection in capillary electrophoresis,Maurice innovatively adopts real-time full column imaging and isoelectric focusing technology. While separating, a linear CCD camera images the entire capillary tube, achieving full monitoring of the entire separation process. This not only shortens detection time, enhances detection resolution, but also greatly improves data reproducibility.

uv absorptionUV280nm， It is a classic iCIEF isoelectric focusing electrophoresis detection channel.

Fluorescence detection is achieved by utilizing the spontaneous fluorescence of aromatic amino acids (tryptophan, tyrosine, phenylalanine) without the need for dyes.

Maurice can simultaneously perform dual channel detection of ultraviolet absorption and spontaneous fluorescence, which can obtain the results of classical methods, as well as increase detection sensitivity through fluorescence, resulting in better signal-to-noise ratioCompared to.

Maurice achieved high repeatability between different instruments by using assembly free capillary cartridges.

Five Maurice tubes were used with five different batch numbers of capillary cartridges to perform multiple tests on the same IgG standard, and the results were highly consistent.

Assembly free, plug and play

Avoid unstable testing caused by manual assembly

No additional pipelines, maintenance free

Avoid frequent blockage of pipelines

Excellent separation medium

Low voltage, low heat generation

Built in anti backflow system

Avoid cross contamination

Maurice's Characteristics：

high resolution&Wide detection range

Excellent repeatability

High universality, suitable for analysis of various protein drugs

Rapid method development, easy transfer of platform methods

Technical parameters: